SignaLife

The Future of Blood Gas
Monitoring is Non-Invasive

Learn More Clinical Validation

Why It Matters

The Pain

Today's blood gas monitoring still requires drawing blood

For premature babies this can mean dozens of painful heel pricks

For critically ill adults it means repeated arterial punctures

These procedures are painful, invasive, expensive - and provide only snapshots instead of continuous information

200M+Blood gas tests annually

$15BAnnual global spending

MillionsPainful blood draws every year

200M+Blood gas tests annually

$15BAnnual global spending

MillionsPainful blood draws every year

The SignaLife Platform

One Platform
From Critical Care to Continuous Care

Continuous Blood Gas & pH Monitoring
Without Blood Draws

ICU & NICUBeachhead

Most urgent unmet need. Critically ill adults and premature newborns require continuous monitoring.

OR, ER & Internal Wards

Expansion across hospital departments where continuous blood gas insight improves outcomes.

Home Care

Home monitoring and hospital-at-home — bringing critical care insight beyond the hospital walls.

Wearables

Implement the SignaLife technology onto wearable devices for continuous, non-invasive monitoring on the go.

The Science

What is pH?

The vital sign nobody monitors continuously.

pH measures the balance of acidity and alkalinity in the blood. It is critical for enzyme activity, neurotransmitter function, and is often the earliest signal of a developing medical emergency - long before vital signs like heart rate or blood pressure shift.

Today, pH is measured by drawing blood - a process that is invasive, intermittent, and painful. Between measurements, critical changes can go undetected.

Blood pH Range

6.8 — Acidosis7.35–7.45 Normal7.8 — Alkalosis

Why it matters

Even small deviations can signal respiratory failure, sepsis, or metabolic crisis - conditions where minutes matter.

The current gap

Arterial blood gas draws are painful, costly, and offer only a snapshot - not a continuous view of patient status.

What We Measure

Six vital parameters
One continuous stream

SignaLife monitors a wide range of blood chemistry and cardiorespiratory parameters - non-invasively, and continuously.

Blood pH

The primary indicator of acid-base balance - the earliest warning of metabolic or respiratory crisis.

pCO₂

Carbon Dioxide

Reflects respiratory function and ventilation adequacy - critical in ICU and ventilated patients.

HCO₃⁻

Bicarbonate

The kidneys' buffer against acid - a key indicator of metabolic status and compensation.

Lac

Lactate

A marker of tissue oxygen deprivation - elevated lactate signals shock or impaired perfusion.

SpO₂

Oxygen Saturation

Continuous pulse oximetry showing the percentage of haemoglobin carrying oxygen.

♥

Pulse Rate

Heart rate derived from the optical signal - eliminating the need for a separate monitoring device.

The Technology

Novel Physics Enabled by AI

Data Refinement

Multi-channel noise canceling with single-channel AGC
Location finding algorithm for maximal signal quality

Signal Processing

Multi-wavelength PPG analysis
Robust algorithms interpret raw data into actionable insights

Physics Based AI

Novel modeling of light's pathway through tissue
Tailored AI training framework based on our physics modeling

Machine Learning

Clinical Validation

Clinical evidence is
already underway

SignaLife's technology is being validated in leading hospitals across Israel - generating real clinical data.

In the Lab

Clinical Experience

Hundreds of lab tests covering wide range beyond biological limits (SpO₂, pCO₂, pH)

ICU

Assuta Ashdod

75 adult patients recruited
Thousands of blood comparisons
Promising correlation with ABG tests

Active Trial

NICU

Sheba Medical Center

<10 premature babies
Safety confirmed
Trial expanding - approval for babies of 800 gr

Active Trial

NICU Patient - Photo Placeholder

Patients

The gift of health starts with not causing harm

At SignaLife, we've developed a technology to give patients - from newborns to adults in critical care - the monitoring they need without the pain.

ICU Clinician - Photo Placeholder

Clinicians

Breakthrough data for the clinicians who need it most

“Continuous real-time pH monitoring gives us a clear, ongoing picture of a neonate's acid-base status, rather than relying on isolated ABG snapshots. It helps us detect critical changes earlier, reduces the stress and pain of repeated arterial sticks, and allows for more precise, timely interventions to protect these vulnerable patients.”
Physician, NICU

Who Are We?

Led by experience
Driven by mission

SignaLife is led by a team of experienced professionals dedicated to advancing healthcare through innovative, non-invasive monitoring solutions. With expertise across business development, medical innovation, and R&D, our leaders bring decades of experience from life sciences, healthcare, and medical device industries.

Our mission is to provide real-time, AI-driven blood gas and pH monitoring solutions for ICU and NICU patients, empowering healthcare providers with reliable insights for better patient outcomes

The Team